Immunomodulatory effects the aqueous extract of Strychnos camptoneura (Loganiaceae) leaves in Swiss mice

Strychnos camptoneura (Loganiaceae) is used in Congolese traditional medicine to treat various diseases such as malaria and diabetes, but not much known about its effects on the immune system. Therefore, purpose of this study was investigate immunomodulatory properties S. leaves. Mice were treated with aqueous extract leaves (100 200 mg/kg); those administered reverse osmosis water β-1,3-glucan (150 mg/kg) negative positive controls, respectively. The measured 24 h post-treatment by quantifying production cytokines, number myeloid lymphoid cells. Treated mice showed a significant IL-4 IL-10 compared animals (P <0.001). Similar β-1,3-glucan, both doses markedly increased macrophages, dendritic cells, CD4+ T NK cells treated-mice, CD8+T These findings suggest that possess properties. Further studies are needed determine phytochemicals these signaling pathways involved immunomodulation. This would help better understand valorize therapeutic potential camptoneura. Key words: camptoneura, effects, mice.